In addition to the University of Nottingham 5 other UK Universities were awarded funding to develop their own Pathology Node.
The University of Manchester
The University of Edinburgh
The University of Glasgow
The University of Leicester
Developing biomarker based molecular pathology tests will be a major focus of the Manchester node with the initial work aimed at creating tests to diagnose, pick the right treatment and asses the response to treatment for a range of inflammatory conditions including rheumatoid arthritis, lupus and psoriasi.
The Edinburgh-St Andrews Consortium will bring molecular diagnostics into mainstream medicine by use of modern genome technologies and information across a range of diseases. The consortium will integrate state-of-the-art genomic and epigenomic methods for diagnosis of acutely ill children and will develop ‘liquid biopsies’ for managing cancer through analysis of circulating tumour DNA.
The Newcastle node will focus on developing new lab tests for rare and chronic diseases and will also be involved in training the next generation of molecular pathologists who will be vital in the delivery of precision medicine.
The Glasgow Molecular Pathology Node will integrate pathology, genomics and informatics. It will be located at the Queen Elizabeth University Hospital campus where the University of Glasgow has already established a world-leading reputation in precision medicine, including the £20 million Stratified Medicine Scotland Innovation Centre, £32 million Imaging Centre of Excellence, and £30 million Queen Elizabeth Teaching and Learning Centre including incubators for industry.
The air we breathe out contains a cocktail of volatile organic compounds that give a snapshot of the biological processes taking place in the lung and beyond. The Leicester node will help develop breath analysis tests that use the same technology as that used to detect explosives in war zones. It’s hoped these could give an instant diagnosis and help doctors pick the best treatments for a range of conditions, including cancers, respiratory infections and diseases such as asthma and chronic obstructive pulmonary disease.