The University of Nottingham has been awarded a Newton Fund to study Improving Clinical Outcome in Indonesia with a Novel diagnostic test for Colorectal Cancer (ICONICC).
As part of this project we will develop UK-Indonesia training schools and Focus Group Discussion (FGD) to promote knowledge exchange and adoption of new molecular test into clinical practice. The Molecular Diagnostics Training School (MDTS) and Image Analysis Training Schools (IATS) will form part of this delivery. Please see our course pages for more details...
Improving Clinical Outcome in Indonesia with a Novel diagnostic test for Colorectal Cancer (ICONICC)
35,000 cases of colorectal cancer (CRC) occur per annum in Indonesia with around 35% of cases occurring in patients under 50 years of age (compared to 5% in UK). They have poor outcomes and many cases will be inherited.
CRC is managed using surgery, with around 90% of cases also requiring chemotherapy. Standard therapy is 5FU but if the patient has a feature called deficient Mismatch Repair (dMMR), they will not respond and may do worse. They may respond to alternatives e.g. Irinotecan.
There is a need to identify (i) cases which are dMMR to prevent ineffective therapy and (ii) patients with inherited cancer to improve lives by early treatment. This project addresses BOTH of these.
Success will reduce the economic burden on the Indonesian health care system and remove the effects of loss of productivity. In this project, we will
(a) Implement a new molecular test to detect both dMMR and inherited form of CRC
(b) Perform a sophisticated analysis of CRCs: an in-depth analysis of CRC in young patients to explore disease biology
(c) Develop UK-Indonesia training schools and Focus Group Discussion (FGD) to promote knowledge exchange and adoption of new molecular test into clinical practice.
The expected impacts of this project include the commercialization and implementation of the new molecular test which will lead to the prevention of approximately 5000 cases per year of over treatment and ineffective chemotherapy, and detecting about 2450 inherited cases of CRC per year to allow the prophylactic therapy and surveillance of family members for early detection.
In addition, the project will also contribute to the upskilling of Indonesia health care and research staff in the field of molecular diagnostics to generate new data for the scientific community and new areas of research, particularly with regard to the high incidence of young patients with CRC in the country.
This work was supported by a [Institutional Links] grant, ID , under the [Newton Institutional Link-Indonesia KLN Fund] partnership. The grant is funded by the UK Department for Business, Energy and Industrial Strategy and [Indonesia Ministry of Research Technology & Higher Education] and delivered by the British Council. For further information, please visit www.newtonfund.ac.uk